Quest rewards you may (not) want to skip
Full list (also posted on my PoE2 related X account: https://x.com/poe2tips):
Act I
- A1 Mud Barrows - Devourer - L1 support gem
- A1 Clearfell - Beira - +10% cold res ❗
- A1 Clearfell - Abandoned stash - L1 skill gem
- A1 Gerlwood - Brambleghast - L2 skill Gem
- A1 Grim Tangle - Rotten Druid - L1 support Gem
- A1 Cemetery Of Eternals - Ancient Ruins - Normal/Magic Ring
- A1 Hunting Ground - Ritual Altar - L4 skill Gem
- A1 Hunting Ground - Crowbell - 2 skill points ❗
- A1 Hunting Ground - Dryadic Ritual - L1 support gem
- A1 Freythorn - King in the Mists - +30 spirit + L4 spirit gem ❗
- A1 Ogham Farmlands - Una's Hut - 2 skill points ❗
- A1 Ogham Farmlands - Crop Circle - L4 skill gem
- A1 Manor Ramparts - Gallows - L1 support Gem
- A1 Ogham Manor - Candlemass - +20 life ❗
Act II
- A2 Traitor's Passage - Balbala - Ascendancy Trial Key
- A2 Halani Gates - Forward Command Tent - Regular drop
- A2 Keth - Kabala - 2 skill points ❗
- A2 Lost City - Rare Tomb 0 L6 spirit gem
- A2 Buried Shrines - Guarded Sarcophagus - L? skill gem
- A2 Buried Shrines - Elemental Offering - res ring choice
- A2 Mastodon Badlands - Shrine of Bones - L1 support gem
- A2 Valley of the Titans - Ancient Vows - one of: 30% Increased Charm Charges, 15% Mana Recovery from Flasks ❗
- A2 Deshar - Watchful Twins - regular drop
- A2 Deshar - Final Letter - 2 skill points ❗
- A2 Spires of Deshar - Sisters of Garukhan - +10 lightning res ❗
Act III
- A3 Sandswept Marsh - Orok Campfire - Lesser Jeweller's Orb ❗
- A3 Sandswept Marsh - Rootdredge - regular drop
- A3 Sandswept Marsh - Hanging Tree - Magic Ring (high change for Amethyst?)
- A3 Jungle Ruins - Jungle Grave - Rare belt
- A3 Jungle Ruins - Mighty Silverfist - 2 skill points ❗
- A3 Venom Crypts - Venom Draught - one of: 25% stun thershold, 30% elemental alinement threshold, 25% mana regen ❗
- A3 Chimeral Wetlands - Ravaged Camp - regular drop
- A3 Chimeral Wetlands - Tooxic Bloom - Orb of Alchemy?
- A3 Azak Bog - Ignagduk - +30 spirit, L10 spirit gem + blue charm ❗
- A3 Jiquani's Machinarium - Blackjaw - +10% fire res ❗
- A3 Jiquani's Sanctum - Zicoatl - L10 skill gem
- A3 Jiquani's Sanctum - Pacquate's Mechanism - corruption device
- A3 Matlan Waterways - Narag's Hut - regular drop
- A3 Molten Vault - Mektul - L10 skill gem + 1k gold
- A3 Apex of Filth - Claudron Keeper - high quality flasks
- A3 Utzaal - Chaos Statue - Inscribed Ultimatum 4 trials
- A3 Aggorat - Blood Sacrifice - 2 skill points ❗
Act IV
- A4 Mud Barrows - Devourer - L11 support Gem
- A4 Clearfell - Beira - +10% cold res ❗
- A4 Gerlwood - Brambleghast - L11 skill Gem
- A4 Grim Tangle - Rotten Druid - L2 support Gem
- A4 Cemetery Of Eternals - Ancient Ruins - Magic Ring
- A4 Hunting Ground - Ritual Altar - regular drop and prizes
- A4 Hunting Ground - Crowbell - 2 skill points ❗
- A4 Hunting Ground - Dryadic Ritual - regular drop
- A4 Freythorn - King in the Mists - jewel?/regular drop
- A4 Ogham Farmlands - Crop Circle - L12 skill gem
- A4 Ogham Farmlands - Una's Hut - 2 skill points ❗
- A4 Manor Ramparts - Gallows - L1 support Gem
- A4 Ogham Manor - Candlemass - +8% maximum life ❗
Act V
- A5 Traitor's Passage - Balbala - Ascendancy Trial Key?
- A5 Halani Gates - Forward Command Tent - regular drop
- A5 Mastodon Badlands - Shrine of Bones - L13 skill gem
- A5 Keth - Kabala - 2 skill points ❗
- A5 Lost City - Rare Tomb - L12 spirit gem
- A5 Valley of the Titans - Ancient Vows - one of: 30% increased Charm Charges gained or 15% increased Life Recovery from Flasks ❗
- A5 Deshar - Watchful Twins - regular drop
- A5 Deshar - Final Letter - 2 skill points ❗
- A5 Path of Mourning - Shifting Vases - L13 skill gem
- A5 Buried Shrines - Guarded Sarcophagus - L13 skill gem
- A5 Buried Shrines - Elemental Offering - res ring choice
- A5 Spires of Deshar - Sisters of Garukhan - +10 lightning res ❗
Act VI
- A6 Sandswept Marsh - Hanging Tree - Magic Ring
- A6 Sandswept Marsh - Orok Campfire - Lesser Jeweller's Orb ❗
- A6 Sandswept Marsh - Rootdredge - regular drop
- A6 Jungle Ruins - Mighty Silverfist - 2 skill points ❗
- A6 Jungle Ruins - Jungle Grave - Rare belt
- A6 Venom Crypts - Venom Draught - one of: 10% chaos res, +5 all attributes, 15% reduced slowing potency of debuffs on you ❗
- A6 Infested Barrens - Troubled Camp - Merchant
- A6 Azak Bog - Ignagduk - +40 spirit, LVL 14 spirit gem + blue charm ❗
- A6 Jiquani's Machinarium - Blackjaw - +10% Fire Res ❗
- A6 Jiquani's Sanctum - Zicoatl - L14 skill gem
- A6 Jiquani's Sanctum - Pacquate's Mechanism - corruption device
- A6 Matlan Waterways - Narag's Hut - regular drop
- A6 Molten Vault - Mektul - L14 skill gem
- A6 Apex of Filth - Claudron Keeper - high quality flasks
- A6 Utzaal - Chaos Statue - Inscribed Ultimatum 7 trials
- A6 Aggorat - Blood Sacrifice - 2 skill points ❗